What causes up regulation of receptors?

What causes up regulation of receptors?

What causes up regulation of receptors?

Upregulation (i.e., increase in the number) of receptors occurs when the activity of the receptor is lower than usual (e.g., due to long-term administration of an antagonist). For example, administration of beta-blockers upregulates β adrenoreceptors. BE

When does up regulation occur?

Upregulation: An increase in the number of receptors on the surface of target cells, making the cells more sensitive to a hormone or another agent. For example, there is an increase in uterine oxytocin receptors in the third trimester of pregnancy, promoting the contraction of the smooth muscle of the uterus. BE

What does upregulation of receptors mean?

Upregulation refers to the increase in receptor sensitivity seen in the setting of lack of agonist stimulation or prolonged presence of a receptor antagonist.

What is the difference between upregulation and downregulation?

Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.

Do agonists cause upregulation?

A mechanism for the increased or decreased sensitivity to agonists and antagonist drugs suggests that decreased exposure to an agonist results in an increase in the number of receptors (upregulation), while increased exposure to an agonist can result in a decrease in the number of receptors (downregulation).

Can cause down regulation of a target cell?

For example, the presence of a significant level of a hormone circulating in the bloodstream can cause its target cells to decrease their number of receptors for that hormone. This process is called downregulation, and it allows cells to become less reactive to the excessive hormone levels.

What is an example of up-regulation?

Upregulation: An increase in the number of receptors on the surface of target cells, making the cells more sensitive to a hormone or another agent. For example, there is an increase in uterine oxytocin receptors in the third trimester of pregnancy, promoting the contraction of the smooth muscle of the uterus.

What is up-regulation of genes?

Up-regulation is a process that occurs within a cell triggered by a signal (originating internal or external to the cell), which results in increased expression of one or more genes and as a result the proteins encoded by those genes.

What does upregulation of a gene mean?

In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus. The complementary process that involves increases of such components is called upregulation.

What is the purpose of upregulation?

Upregulation: An increase in the number of receptors on the surface of target cells, making the cells more sensitive to a hormone or another agent. For example, there is an increase in uterine oxytocin receptors in the third trimester of pregnancy, promoting the contraction of the smooth muscle of the uterus.

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